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Pfizer Inc. Senior Computational Geneticist in Denver, Colorado

ROLE SUMMARYThe advance of human genetics in recent years driven by the large scale humangenome-sequencing and genome-wide association in multiple disease areas hasprovided the research community and pharmaceutical industry an unprecedentedability to utilize this information and technology to facilitate innovativedrug discovery and development. Human genetics is sufficiently mature to aidthe drug discovery process in several important areas.A combination of genetic epidemiology, quantitative genetics,computational biology, functional genomics and other 'omics data isfacilitating our ability to identify mechanisms, indications, patients andbiomarkers, guided by an evidence base in humans.Within the Internal Medicine Research Unit (IMRU), one of the keystrategic focus areas is identifying novel therapies to improve metabolichomeostasis in patients suffering from a range of metabolic diseases,including NAFLD, NASH, diabetes, obesity, and abnormalities in cardiacmetabolism.The integrative biology team is part of IMRU and is focused onintegrating human genetics and human biology, functional genetics,computational biology to support target identification, target validationand dThe IMRU Integrative Biology Team group is looking for an expert in humangenetics with sound knowledge of applying quantitative methods to humangenetics and genomics as tools to integrate human genetics evidence ofgene-disease associations for target discovery/validation,biomarker/indication identification and patient stratification throughgenetic association and other 'omics analyses.The ideal candidate will also work with our external partners andcollaborators to help manage external collaborations, ensure the delivery ofhigh quality data during specified timelines, and to incorporate resultsinto target identification and validation.The applied human genetics scientist position offers an opportunity to executescience-based drug discovery within one of the world's leading developers ofhuman therapeutics, at Pfizer's Kendall Square research facility inCambridge Massachusetts.ROLE RESPONSIBILITIESProvide quantitative genetics expertise and conduct analyses to deriveimpactful results through interactions with biologists within the InternalMedicine Research Unit.Provide expertise and quantitative skills on the application of genetics andfunctional genomics to inform project teams in:- Identification of novel therapeutic targets.- Review and validation of therapeutic hypotheses.- Mechanistic understanding of disease pathogenesis and causal pathways.- Innovative approaches to identifying mechanism related biomarkers viaintegrating genetics with clinical and omic datasets.- Identification of potential disease indications.- Matching novel therapies to patients with relevant disease sub-types.Ensure high-quality genetic and 'omics data is incorporated into exploratoryresearch by interacting with internal partners in statistics,bioinformatics, computational biology, clinicians, and project leadersto drive genetic data analysis, data integration, and genetic methodology.Work in collaboration with research biologists and project teams to identifythe best opportunities to translate genetic and related data to inform andprioritize assets in the portfolio; and with clinical teams to informoptimum patient selection, stratification and trial design.Manage, develop and maintain internal and external collaborative projects tospecified timelines and milestones.Communicate study findings and analyses with internal partners,leadership, administration, and collaborators.Manage, support and promote relationships with the external community thatcan add value to target selection and validation at Pfizer.BASIC QUALIFICATIONSBackground in biological and/or quantitative sciences; PhD andpost-doctoral experience in genetics, statistical genetics, or geneticepidemiology with two years relevant experience.Sound statistical and quantitative skills, with knowledge of epidemiologicalprincipal