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Pfizer Principal Scientist, Enzymology in Boulder, Colorado

Pfizer-Boulder (formerly Array BioPharma) is focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. We recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.

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We seek an exceptional scientist with demonstrated experience employing steady state and/or biophysical techniques to characterize the interaction of small molecule inhibitors with their protein targets. This person will be responsible for assay development, screening, lead characterization and lead optimization in a collaborative team environment, working closely with structural biologists, protein chemists, computational and medicinal chemists. The candidate will take a functional leadership role on these project teams in a fast-paced drug discovery environment. Additionally, the candidate will mentor other members of the group in mechanistic enzymology.


  • Independently lead enzymology effort on project team(s) with assay development, HTS, assay support and mechanism of action studies

  • Document and provide regular, written and/or verbal reports of experimental findings as well as offering strategic guidance to the project team(s)

  • Mentor more junior Enzymology Group members and other Biology Department members in mechanistic enzymology

  • Solve complex problems in mechanistic enzymology related to drug discovery

  • Present at group meetings, global project team meetings, and site meetings

  • Collaborate with medicinal chemists, computational chemists, structural biologists, and cell biologists to pursue the most promising small molecule compounds through candidate identification and selection

  • May supervise research associates and/or scientists


  • Ph.D. in biochemistry or related field with 5+ years of postdoctoral experience and relevant industry experience

  • Advanced knowledge of mechanistic enzymology and biophysical technologies supported by peer-reviewed publications

  • Demonstrated expertise determining enzyme mechanisms and inhibitor MOA's using steady-state kinetics and related technologies

  • Ability to manage an independent research program with no supervision including designing, planning, executing, interpreting and documenting experiments

  • Strong organizational and interpersonal skills

  • Ability to work well with team members across functional areas

  • Self-motivation with a desire to learn

  • Demonstrated scientific excellence with attention to detail

  • Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds

  • Ability to represent discovery teams and communicate goals/deliverables to senior management and/or governance committees


  • Small molecule drug discovery experience in an industrial setting

  • Experience in laboratory robotics and high throughput screening

  • Experience with general biochemical and kinetic-based assay technologies (e.g., FI, FP, TR-FRET, L anthaScreen™, AlphaScreen®, luminescence)

  • Experience in biophysical techniques for characterizing interactions between proteins and ligands

  • Experience in mentoring and/or leading Ph.D. level and non-Ph.D. level scientists

  • Experience in curve-fitting, statistics and assay optimization (DOE)

  • Proficiency with Microsoft Office and associated applications (e.g., XLfit), Spotfire, Design-Expert


  • Eligible for Relocation Package

  • Eligible for Employee Referral Bonus

  • #LI-PFE

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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