Pfizer Principal Scientist, Enzymology in Boulder, Colorado
Pfizer-Boulder (formerly Array BioPharma) is focused on the discovery, development and commercialization of targeted small molecule drugs to treat patients afflicted with cancer. We recently received approval and launched BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of patients with BRAF mutated melanoma. These products have also been granted Breakthrough Therapy Designation by the FDA for BRAF mutated CRC.
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We seek an exceptional scientist with demonstrated experience employing steady state and/or biophysical techniques to characterize the interaction of small molecule inhibitors with their protein targets. This person will be responsible for assay development, screening, lead characterization and lead optimization in a collaborative team environment, working closely with structural biologists, protein chemists, computational and medicinal chemists. The candidate will take a functional leadership role on these project teams in a fast-paced drug discovery environment. Additionally, the candidate will mentor other members of the group in mechanistic enzymology.
Independently lead enzymology effort on project team(s) with assay development, HTS, assay support and mechanism of action studies
Document and provide regular, written and/or verbal reports of experimental findings as well as offering strategic guidance to the project team(s)
Mentor more junior Enzymology Group members and other Biology Department members in mechanistic enzymology
Solve complex problems in mechanistic enzymology related to drug discovery
Present at group meetings, global project team meetings, and site meetings
Collaborate with medicinal chemists, computational chemists, structural biologists, and cell biologists to pursue the most promising small molecule compounds through candidate identification and selection
May supervise research associates and/or scientists
Ph.D. in biochemistry or related field with 5+ years of postdoctoral experience and relevant industry experience
Advanced knowledge of mechanistic enzymology and biophysical technologies supported by peer-reviewed publications
Demonstrated expertise determining enzyme mechanisms and inhibitor MOA's using steady-state kinetics and related technologies
Ability to manage an independent research program with no supervision including designing, planning, executing, interpreting and documenting experiments
Strong organizational and interpersonal skills
Ability to work well with team members across functional areas
Self-motivation with a desire to learn
Demonstrated scientific excellence with attention to detail
Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds
Ability to represent discovery teams and communicate goals/deliverables to senior management and/or governance committees
Small molecule drug discovery experience in an industrial setting
Experience in laboratory robotics and high throughput screening
Experience with general biochemical and kinetic-based assay technologies (e.g., FI, FP, TR-FRET, L anthaScreen™, AlphaScreen®, luminescence)
Experience in biophysical techniques for characterizing interactions between proteins and ligands
Experience in mentoring and/or leading Ph.D. level and non-Ph.D. level scientists
Experience in curve-fitting, statistics and assay optimization (DOE)
Proficiency with Microsoft Office and associated applications (e.g., XLfit), Spotfire, Design-Expert
OTHER JOB DETAILS
Eligible for Relocation Package
Eligible for Employee Referral Bonus
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Research and Development