University of Colorado Post-Doctoral Fellow in Aurora, Colorado
University of Colorado – School of Medicine
This position will be responsible for the translational project to determine the mechanisms of chemotherapy-induced pediatric bladder dysfunction in animal models of lower urinary tract disorders. Research in the Urology Research laboratory utilizes state-of-the-art technologies, including patch-clamp recordings in primary smooth muscle cell cultures and human cell lines, bladder innervating sensory and motor neurons, in vitro contractility studies, and pharmacogenetics in combination with in vivo urodynamic assessment of bladder function.
Specific Position Duties with Percentages of Time
Investigate/in vivo/and/in vitro/pathways and mechanisms of pediatric voiding dysfunction in animal models of bladder pathophysiology;
Determine the effects of chemotherapeutic drugs on bladder function, and what therapeutic approaches can be used to reduce bladder hyperalgesia, pelvic pain and normalize micturition
Perform experiments involving nucleic acid and protein isolation, RT-PCR and qPCR, Western blotting
Learn new physiological/functional methods for/in vivo/and/in vitro/evaluation of bladder function
Prepare data for presentations and publications
Presentation of the data at national and international meetings
Train graduate students and residents during lab rotations
Attend weekly lab meetings, and individual meetings with the mentor(s)
Additional participation in the projects of adult urological research program focused on urological chronic pelvic pain syndromes and neurogenic voiding dysfunction will be required as needed
PhD (or equivalent) in biology, physiology, biochemistry, neuroscience or related discipline
Experience in mutagenesis; tissue-specific transgenic vectors; qRT-PCR, Western Blot;in vivo co-immunoprecipitation; confocal microscopy, FACS, cell culture, transfections; generatiion of KO mice, genotyping.
Excellent communication and interpersonal skills
First author publications in peer-reviewed biomedical journals
Experience with optogenetic approaches, and/in vivo/electrophysiology
Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located atEmployee Services.
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Organization: *U0001 -- DENVER & ANSCHUTZ MED CAMPUS
Title: Post-Doctoral Fellow
Requisition ID: 11906